The BioCell™ allows for the temperature-dependent study of living cells or single molecules with the CellHesion® in their native environment. It is therefore particularly suited for applications in cell biology and biomedical research. As an add-on for inverted optical microscopes the CellHesion® in combination with the BioCell™ offers the unique possibility to simultaneously study temperature-dependent processes like cell motility and metabolism with the CellHesion® and simultaneous advanced optical imaging. During CellHesion® measurement all the optical microscope‘s operation modes, in particular contrast techniques, remain constantly available. Even high-resolution fluorescence confocal microscopy and single-molecule fluorescence techniques are possible since objective lenses with highest numerical aperture can be used.